Background: In today's world, eating out has become the preferred choice rather than the exception. We all love trying out new food joints and tingle our taste buds with various cuisines but it is important to note that eating out comes with its share of risks and ailments. One of the most common effects is worm infestation in nursing students, especially in paying guest. Also, being a developing nation with its share of illiteracy. hygiene is not given much priority by chefs and food handlers. The main form of transmission is through faeco-oral route. Other modes are through sexual contact and also carriers like flies, cockroaches and rodents. Common worms that humans are susceptible to include roundworm, hookworm, tapeworm and threadworm. Objectives of the study: To assess the level of knowledge regarding prevention and management of worm infestations among nursing students residing in paying guest accommodations. To find out the association between knowledge scores and selected demographic variables such as age, year of study, type of accommodation and previous knowledge regarding worm infestations. To develop a self-instructional module on prevention and management of worm infestations for nursing students based on the findings of the study. Materials and Methods: A conceptual framework is a theoretical approach to the study the problems that are scientifically based and emphasize the selection, arrangement and classification of its concepts. A conceptual model or conceptual frame work broadly explains phenomena of interest, expresses assumption and reflects a philosophical stance. A descriptive survey approach by using non probability convenience sampling technique was adopted to collect the data. Structured knowledge questionnaire was administered to 60 nursing students who are residing at paying guest, Nelamangala, Bangalore. Results: The mean knowledge score was 40.5% and SD 7.03. The highest mean knowledge score is related to management of Worm Infestations (44.5%), whereas, the lowest mean knowledge score is related to Risk factors, causes and transmission of Worm Infestations (36%). The aspect wise mean knowledge score ranged between 30% to 44.5%. The result shows that 60% nursing students possess inadequate knowledge, 25% nursing students possess moderately adequate knowledge and 15% nursing students possess adequate knowledge regarding the Worm Infestations and its prevention. Conclusion: There was significant relationship found between the demographic variables such as age, family history of Worm Infestations and knowledge of nursing students but there was no significant relationship found between the demographic variables such as educational status, family monthly income, gender, Source of information and knowledge level of adults.